Sheffield
University
Development
of computational methods for 3D similarity and structure-based design
techniques in lead optimisation (EPSRC CASE)
The lead optimisation
phase of drug discovery involves successive cycles of design and
synthesis in order to identify structures within a chemical series
that have desired properties. This project involves the development
of software tools based on 3D similarity methods to assist in this
process.
URL: NONE
Contact: Dr. Val Gillet, Senior Lecturer, [email protected]
Dates: October 2002 - September 2005
Funding: GlaxoSmithKline
BFIT: Barnsley
Fast Track to Information Technology-phase 3
This project
is concerned with the employment and training of computer support
technicians from the Barnsley area.
URL:
NONE
Contact: Prof. Bob Usherwood, [email protected]
Dates: September 2002-August 2003
Funding: The National Council on Archives
Analysis
and comparison of three-dimensional nucleic acid structures
This project
is developing computational methods, based on graph theory, for
searching for patterns of bases in nucleic acid 3D structures. The
methods are being developed as part of an ongoing collaboration
with the Department of Molecular Biology and Biotechnology in the
University of Sheffield, and will be based on previous joint studies
of search tools for 3D protein structures.
URL: NONE
Contact: Prof. Peter Willett, Professor, [email protected]
Dates: October 1999 � September 2002
Funding: BBSRC-Bioinformatics Programme
The Archives and Records Management Workforce Study:
recruitment, training and leadership for the UK sector
The project will help the sector to retain,
support and develop a workforce appropriate to its current and future
needs. It will seek to create a coherent framework for future professional
recruitment, education, training and development, and help to improve
responsiveness to change. It will increase the amount and quality
of information available to managers, educators, and selectors,
leading to more effective decision- making.
URL: NONE
Contact: Prof. Bob Usherwood, [email protected]
Dates: September 2002-August 2003
Funding: The National Council on Archives
CLARITY:
Cross language information retrieval and organization of text and
audio documents
CLARITY is an
EU-funded research project with the aim to provide a cross language
information retrieval system for text and audio documents. See
web site at clarity.shef.ac.uk
Contact: Dr. Mark Sanderson, Lecturer, [email protected]
Dates: December 2000 � November 2003
Funding: EC-Framework V Research & Technological
Developments
Computer
analysis of high throughput screening data (EPSRC CASE)
This project is developing computational
methods for the analysis of the large volumes of structural and
bioactivity data generated by high-throughput screening progarmmes
in the pharmaceutical and agrochemical industries.
URL: NONE
Contact: Prof. Peter Willett, Professor, [email protected]
Dates: October 1999 � September 2002
Funding: Eli Lilly
Concept-based
interactive query expansion support tool (CIQUEST)
An investigation into a novel approach for
clustering documents to generate concepts displayed as hierarchies
for supporting interactive query expansion. A major emphasis is
to develop a user-based evaluation of the concept tool.
URL: NONE
Contact: Professor Micheline Beaulieu, Head
of Department, [email protected]
Dates: May 2000 � February 2003
Funding: Re:source
The
development of a novel descriptor targeted to high-throughput analysis
in lead exploration and combinatorial library design (BBSRC CASE)
Nothing published yet so still confidential
URL: NONE
Contact: Prof. Peter Willett, Professor, [email protected]
Dates: October 2000 � September 2003
Funding: Novartis Pharmaceuticals UK Ltd.
Development
of a similarity searching algorithm for the virtual screening of
natural product databases
Similarity searching
is an important component of modern systems for handling databases
of small (drug-sized) chemical molecules. This project is evaluating
the appropriateness of such searching methods for databases of natural
product molecules.
URL: NONE
Contact: Prof. Peter Willett, Professor, [email protected]
Dates: October 2000 � September 2002
Funding: Unilever Research
Development
of reduced graphs as novel descriptors for identifying structure-activity
relationships (EPSRC CASE)
Nothing published yet so still confidential
URL: NONE
Contact: Dr. Val Gillet, Senior Lecturer,
[email protected]
Dates: October 2000 � September 2003
Funding: AstraZeneca
Digital
libraries, text archives and e-text centers: a history of the formation
and development of electronic text collections in the humanities
1970 to 2001
This project aims to examine the history
of the formation and development of electronic text collections
in the humanities both in Britain and in the USA.
URL: NONE
Contact: Dr. Claire Warwick, Lecturer, [email protected]
Dates: October 2001 � October 2002
Funding: The British Academy
Discrete
mathematical approaches to chemical information retrieval
This project is developing new methods for
similarity searching in databases of 2D chemical structures, focusing
on similarity measures that are based on maximum common subgraph
isomorphism algorithms.
URL: NONE
Contact: Prof. Peter Willett, Professor, [email protected]
Dates: October 2000 � September 2003
Funding: Parke-Davis Pharmaceutical Research Inc.
Education
for evidence-based citizenship: improving pupil's information seeking
skills
This project is concerned with the investigation
of secondary school pupil's information seeking skills.
URL: NONE
Contact: Mr. Nigel Ford, Reader, [email protected]
Dates: July 2001 � June 2004
Funding: AHRB
Genome analysis
using DNA structure
This project is developing new methods for
substructure and similarity searching in computed 3D nucleic acid
structures, in collaboration with the Department of Chemistry in
the University of Sheffield.
URL: NONE
Contact: Prof. Peter Willett, Professor, [email protected]
Dates: January 2001 � December 2003
Funding: BBSRC-Bioinformatics Programme
Libraries must also be buildings? A new library impact
study
With the advent of ICT the idea of the public
library as a physical space and the role it plays in the wider community
is coming into question. The opening of several new library buildings
in the past year provides a unique opportunity to assess the impact
some of these new public library buildings have on their user communities.
In making this assessment the research will identify the variables
that affect the kind of impact that is made, and develop a methodology
for the future assessment of impact
URL: NONE
Contact: Prof. Bob Usherwood, [email protected]
Dates: April 2002 � July 2002
Funding: Resource
Methods
for focussed combinatorial library design (BBSRC CASE)
Nothing published yet so still confidential
URL: NONE
Contact: Dr. Val Gillet, Senior Lecturer,
[email protected]
Dates: October 2000 � September 2003
Funding: GlaxoWellcome Research and Development
MIND: Resource
selection and data fusion for multimedia international digital libraries
The key objective of the MIND project is
to address the problems faced by users in terms of their ability
to access and exploit the increasing number of Digital Libraries
available internationally through networks, such as the Internet
and the World Wide Web (WWW).
URL: NONE
Contact: Dr. Mark Sanderson, Lecturer, [email protected]
Dates: January 2001 � July 2003
Funding: EC-Framework V Research & Technological
Developments
MOSART: Music
orchestration systems in algorithmic research and technology
This is a research
training and mobility network project in the area of music informatics.
The project task addresses the following areas: (i) Analysis of
Current Methods for Music Orchestration Systems; (ii) Musical Sound
Understanding and Timbre Modelling; (iii) Control and Virtualisation
of Instruments; (iv) Interactive Musical Performance; (v) Symbolic
Recognition of Musical Patterns and Recomposition; (vi) Symbolic
Recognition of Musical Patterns and Recomposition; (vii) Transfer
and Exploitation. Sheffield is the co-ordinating site for work in
area (vi).
URL: NONE
Contact: Dr. Barry Eaglestone, Senior Lecturer,
[email protected]
Dates: September 2000 � August 2003
Funding: EC-Framework V Research Networks
Probabilistic
prediction of bioactivity using structural descriptors
Nothing published yet so still confidential
URL: NONE
Contact: Prof. Peter Willett, Professor, [email protected]
Dates: November 2000 � November 2003
Funding: Syngenta
Relevant
repositories of public knowledge? Perceptions of archives, libraries
and museums in modern Britain
Using qualitative
and quantiative methodologies and by focusing on Britons� perceptions
and use of archives, libraries and museums when seeking information,
and attempting to understand, contemporary issues, the project will
assess the value of these traditional repositories of public knowledge
in the �information age�
URL: NONE
Contact: Prof. Bob Usherwood, [email protected]
Dates: Oct 2002 � September 2004
Funding: AHRB
SPIRIT: Spatially
aware information retrieval on the Internet
SPIRIT will investigate the applications
of geographical information systems (GIS) to enhance text-based
information retrieval (IR) systems. Sheffield�s part in the project
is to adapt an existing text retrieval system to search a 1 Tb Web
collection using acluster of c-ordinated Unix/Linux machines (probably
a Beowulf cluster); find means of evaluating the accuracy of the
searching system; and integrate GIS information into the text searching
system.
URL: NONE
Contact: Dr. Mark Sanderson, Lecturer, [email protected]
Dates: May 2002 � April 2005
Funding: EC-Framework V Research & Technological
Developments
UK academics�
perceptions of, and pedagogy for, information literacy
This project will look at UK academics� conceptions
of information literacy, thereby identifying implications for information
literacy teaching. The methodology is sensitive to individual and
disciplinary differences and seeks to formulate models and a framework
for educational practice
URL: http://dis.shef.ac.uk/literacy/project/
Contact: Ms. Sheila Webber, Lecturer, [email protected]
Dates: November 2002 � October 2005
Funding: AHRB
The vital
link: reader development and adult basic skills
This joint project with the university's
Department of Education is concerned with the evaluation of the
effectiveness of reader development strategies in terms of their
contribution to reducing the number of people with poor basic skills
URL: NONE
Contact: Prof. Bob Usherwood, Professor, [email protected]
Dates: September 2001 � August 2002
Funding: DCMS/Wolfson Public Libraries Challenge Fund
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